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3) Tissue damage and unintended injury Injections placed too superficially, too deeply, or in the wrong anatomical plane can cause complications such as: significant inflammation and swelling skin irritation or blistering nodules and firmness under the skin uneven contouring damage to nerves or blood vessels in rare cases The submental region is anatomically complex

Once transported into cells, DHA undergoes a GSH-dependent, two-electron reduction to VitC, catalyzed by redox enzymes including glutaredoxin, omega-class glutathione transferases and protein-disulfide isomerase 10,11,12,13

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Results The 43 included studies were published between 2013 and 2025 and originated from diverse regions including Belgium, France, China, and the United States