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Introduction The glucagon-like peptide-1 receptor (GLP-1R), expressed in pancreatic beta cells amongst other tissues including brain, lung, stomach, and heart, is activated by the incretin peptide hormone GLP-1, secreted from enteroendocrine L-cells after food intake (1), to regulate postprandial glucose levels via the potentiation of glucose-dependent insulin secretion (24)

placebo at 6 months] 1.3, 95%CI 0.891.88) in 300 people with HF, with and without type 2 diabetes and with recent decompensation (Margulies et al., 2016)

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Patients with conditions such as obesity, diabetes, and lipodystrophy often have low levels of serum IGF-1