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Key Differences at a Glance Dosing Wegovy pill: Daily tablet on an empty stomach Injectable GLP-1s: Weekly self-injection Weight Loss Wegovy pill: ~1317% at 64 weeks Injectable GLP-1s: ~15%+ at 68 weeks Blood Sugar Impact Wegovy pill: Strong effect on insulin resistance with modest A1c reduction Injectables: Slightly greater A1c reductions overall Side Effects Wegovy pill: Similar GI effects (nausea, diarrhea)