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Nutrition, physical activity, sleep, stress management, social connection and avoiding harmful substances all work together to improve metabolic health

Through these two main actions, GLP-1s can make it easier to stay in a calorie deficit to lose weight, while also improving metabolic health

Priority research needs include large-scale randomized controlled trials to establish efficacy and safety, dose-ranging studies to optimize treatment protocols, long-term safety studies particularly regarding cancer risk, and comparative effectiveness research with established therapies