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Bjerre KL, Madsen LW, Andersen S, et al

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Moreover, our data complements previous observations showing that pre-infusion CD19-CAR T cell products of patients in complete response compared to non- or partial responders have higher mitochondrial volume by 3D confocal microscopy 23 , and that mitochondrial transfer enhances CD19-CAR T cell metabolic fitness and antitumor efficacy in a preclinical model 8

220 Therefore, it is highly important to explore the relationships among lipid and glucose metabolism, mitochondria metabolic function and ferroptosis in metabolic diseases such as diabetes, hyperlipidemia, and obesity