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Smoking also may impair the phase II metabolites, thus creating more estrogen quinone metabolites with a decreased ability to eliminate them.[ref][ref] Therefore, the combo of variants in phase I and phase II genes (genotype report below) with smoking causes a fairly large increase in the risk of cervical, breast, or prostate cancer

Under the agreement, Ascendis will receive up to US$285m in upfront, development, and regulatory milestone payments for the lead programme, along with sales-based milestone payments and tiered royalties

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