Activation of c-Met initiates downstream intracellular cascades that govern cell survival, motogenesis, and dendritic spinogenesis
The combined activation of both pathways appears to produce greater weight loss than GLP-1 activation alone, which is why tirzepatide has shown superior weight loss results compared to semaglutide in head-to-head trials
These may include: A persistent or intermittent metallic, bitter or chemical taste Reduced ability to detect sweet, salty or sour flavours Dry mouth or thick saliva Burning or irritation on the tongue Bad breath or unusual mouth odour Sensitivity to hot or spicy foods Changes in appetite or food enjoyment Bleeding gums, swelling or tenderness Sinus congestion, sore throat or post nasal drip Signs of reflux, such as heartburn or coughing at night The metallic taste may be present even without eating or drinking and may be worse in the morning or after meals
Strategies to minimize reactions include rotating injection sites consistently to avoid repeated trauma to the same area, ensuring the solution is at room temperature before injection (cold injections can increase irritation), injecting slowly rather than quickly, and using a smaller gauge needle for less tissue trauma