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Once inside, the unprotonated amphetamine molecules become rapidly protonated by the acidic environment of the vesicle, which alkalinizes the vesicle matrix and completely dissipates the necessary pH gradient (Wimalasena 2011)(see Figure 2 Mechanism A)

However, specific targeting of the GPCRs in humans might be difficult due to their complex chemistry and diverse functions in different tissues ( Figure 2 )

Disponible en: Chavda VP, Ajabiya J, Teli D, Bojarska J, Apostolopoulos V

There are also specific therapeutic measures, according to the triggering disease, as exemplified by the use of prokinetics in patients with GLP-1 agonist-induced gastroparesis