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In one trial for semaglutide, participants taking a 2.4 mg once-weekly dose lost 14.9% of their body weight over 68 weeks compared to a weight reduction of 2.4% in the placebo group

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As a result, lifestyle interventions alone, such as diet and exercise, are often insufficient, and effective management typically requires a combination of strategies to address the underlying biology of obesity. The group explored data from more than 60,000 patients who originally participated in one of 56 randomized controlled trials (RCTs)

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