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Incretin-based therapies for type 2 diabetes mellitus
You shouldn't take GLP-1s if you have type 1 diabetes, issues with your kidneys or pancreas, or if you are under 18, pregnant, or breastfeeding
Some even go as far to say that, not only will incremental volumes be lower (as a more significant percentage will be won by orals) but also that orals will cannibalize the existing injectable volumes (so not only not a tailwind to future volumes, but also a headwind to existing volumes)
For Korner, whats particularly worrying when it comes to microdosing is the lack of research, given that these medications carry proven cardiovascular and kidney benefits that have never been evaluated at microdose levels
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