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Looking ahead, by optimizing delivery systems, exploring combination therapies (such as SIRT1 with GLP-1 agonists), incorporating SIRT1 gene polymorphisms for personalized treatment, and validating long-term safety, SIRT1 has the potential to evolve from a "promising target" to a "transformative therapy." SIRT1 deacetylates forkhead box class O3 (FOXO3), thereby initiating autophagy

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Stopping the medication temporarily reduces these compounding risks and allows your body to heal without medication-related complications layered on top of surgical stress

The protocol has the Patient Health Questionnaire-9 (PHQ-9) and Columbia-Suicide Severity Rating Scale (C-SSRS) to get a full picture