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Front Neurosci 18:1342944

WO 00/53148 discloses and claims a "method for the treatment of erectile dysfunction which comprises administering to a human subject in need of such treatment an effective amount of an agonist of the melanocortin receptor in combination with an effective amount of a cyclic-GMP- specific phosphodiesterase inhibitor or an alpha-andrenergic receptor antagonist. MT-II is a disclosed melanocortin receptor agonist and sildenafil is a disclosed PDE-5 inhibitor

long-term human safety is not established

Autonomic nervous system imbalance: The interplay between the sympathetic and parasympathetic nervous systems is critical to the initiation and maintenance of AF