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The FMT transfer of Fuzi accompanied by changes in bile acid signaling axis readouts and NLRP3-related metrics suggests that alterations in MetaboliteInflammation Pathways may connect to this convergence endpoint, though ABX necessity verification and closed-loop supplementation/antagonism at the molecular level are still lacking ( Level C Consistency Supplement: In Level C studies, the reduction of pro-inflammatory cytokines, alleviation of histological damage, or mitigation of bone destruction are nearly ubiquitous convergent phenotypes across interventions, supporting the stability of systemic inflammation improvement as a common endpoint

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The CHARMM36-CAMP force filed 58 was adopted for protein, peptides, lipids, and salt ions

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