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TNF is elevated in obesity and positively associated with insulin resistance [43, 44]
In that study, a 25-milligram dose of Novo Nordisk's oral semaglutide helped patients lose up to 16.6% of their weight on average after 64 weeks, according to results from the trial presented at a medical conference in 2024
The Fueled Framework recommends a protein target of 0.7 to 1.0 grams per pound of your goal body weight per day
While GLP-1 medications like semaglutide have helped thousands manage weight effectively, they are not risk-freeand they're not suitable for everyone
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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