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Other contributors may include mast-cell activation, allergy, chronic inflammation, medication effects or reduced intracellular breakdown by HNMT
Future incretin-based therapies Future research in incretin-based treatment of overweight and obesity aims to investigate the potential of combining GLP-1-R agonism with the targeting of other peptide hormones to achieve synergistic effects, with the most prominent targets of interest being the GIPR, the glucagon receptor (GCGR) and the amylin receptor [16]
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