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Hartman ML, Sanyal AJ, Loomba R, et al

An observational cohort study involving 168 pregnant women exposed to GLP-1 receptor agonists during the first trimester found a 2.6% prevalence of major birth defects, comparable to 2.3% in the diabetic reference group

These results were widely covered in medical media and prompted Eli Lilly to advance retatrutide into a large-scale Phase 3 program

Warfarin and other anticoagulants in line with GLP-1 RA SmPCs (e.g., semaglutide), more frequent INR monitoring is advisable when starting retatrutide or changing the dose, as any alteration in gastric motility could affect anticoagulant control