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Real-world users may not optimize nutrition or avoid problematic foods , reducing the magnitude of benefit

Because this peptide operates upstream on Wnt signaling and follicle nutrition rather than through vasodilation, combining the two has become a common research design

High-intensity exercise within 2 to 4 hours of injection can worsen nausea, as both exercise and the medication reduce blood flow to the GI tract

Phase 2 cagrilintide alone ~10.8% body weight reduction at 26 weeks (4.5mg) Phase 2 CagriSema combo ~15.6% body weight reduction at 32 weeks Phase 3 REDEFINE 1 ~22.7% body weight reduction at 68 weeks Phase 2 CagriSema combination trial The Phase 2 trial of CagriSema was published in The Lancet in 2023, and its results attracted immediate attention