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Diphenyleneiodonium (DPI), a flavoenzyme inhibitor, not only prevented the formation of the NFT radical anion in microsomal preparations (Fig

While the magnitude of these benefitsa 10% to 20% reduction in many outcomesis modest, the implications are profound for conditions with limited treatment options

The Zr released from Mn-MOF downregulated GSH efficiently (Figure 5G), thus elevating Mn-MOF-induced ROS concentration, leading to the deactivation of GPX4 and ROS-enhanced ferroptosis