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This is a kind of end-product inhibition that prevents the GSH concentration from rising too high

Human preclinical data 4 show direct hypertrophic effects in human myotubes: IGF-1 increased myotube nuclei, fusion index, and myosin heavy chain content, demonstrating true cellular growth responses that underpin strength and size improvements seen with effective training

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Compared to empty vector reporter, the 5UTR reporter exhibited higher relative luciferase activity in shCtrl cells but lower activity in shGDH1 cells (Fig