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Previous studies have shown that HFD feeding elevates production of reactive oxygen species in adipose tissue and boosts macrophage infiltration and inflammation (19, 21, 22), while chronic inflammation is closely associated with metabolic disorders (23)

3.8 Correlations among gut microbiota, metabolites and immunity To explore the interplay between gut microbiota, microbial metabolites, and the host immune system, we conducted Spearman correlation analysis and visualized the results as a heatmap (Figure 8)

31,32 The primary site of impact is the small intestine, where poor absorption of various nutrients including vitamin B 6 can occur

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