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Additionally, GLP-1 receptor activation in the brainstem, which regulates nausea and vomiting, can contribute to this side effect

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The design of these studies was comparable regarding the tirzepatide doses, starting with 2.5 mg once weekly with dose increases by increments of 2.5 mg every 4 weeks until the randomized final treatment dosages of 5, 10, or 15 mg tirzepatide were reached

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