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However, in certain cases evidence exists of selection at the somatic cell level after X-chromosome inactivation

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Microbiome depletion : Antibiotics, poor diet or stress can wipe out beneficial gut flora, which are protective against dysbiosis and overgrowth, and support normal gut functioning

There is a similar beneficial effect in the rats with the Pringle maneuver, ischemia, reperfusion, and suprahepatic inferior caval vein occlusion (BuddChiari syndrome) (Vukojevic et al., 2018