Contact your healthcare provider for severe or worsening fatigue interfering with daily activities, fatigue accompanied by dizziness, chest pain, severe nausea, inability to keep down fluids for over 24 hours, dark urine, severe abdominal pain, or signs of allergic reaction
This includes severe headaches, vision changes, shortness of breath, chest pain, rapid swelling, and fainting
It impairs BBB permeability by inducing the degradation of tight junction proteins (e.g., occludin, claudin-5), thereby exacerbating neuroinflammation (Vezzani and Baram, 2007
In the context of current cost and resource constraints, these are reasonable, clinically grounded alternatives that still acknowledge that obesity is a chronic disease