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Neither medication is clearly better or worse for fatigue in all cases

GLP-1 medications can be an effective tool to reduce visceral fat, but they work best when paired with nutrition, resistance training, and sustainable lifestyle habits

According to the National Institute of Diabetes and Digestive and Kidney Diseases , GLP-1 medications can support long-term weight management when combined with lifestyle changes and medical supervision

Malabsorption : Some people may have difficulty absorbing vitamin B12 from the diet due to certain medical conditions or the use of certain medications, such as proton pump inhibitors (PPIs) or H2 blockers, which reduce stomach acid production