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A B6-deficient person starting semaglutide faces a double problem: their neurotransmitter synthesis is already compromised, and semaglutide further disrupts the GI and central nervous system pathways that depend on adequate B6 levels

[PUBMED Abstract] Blankenburg S, Knig IR, Moessner R, et al.: Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study

Ding L, Zhang J: Glucagon-like peptide-1 activates endothelial nitric oxide synthase in human umbilical vein endothelial cells

The triple receptor mechanism (GLP-1, GIP, and glucagon) creates synergistic effects that single or dual agonist medications cannot match