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2 , 699706.e691 (2020)
Gastrointestinal AE with cagrisema were more than with semagutide or cagrilintide monotherapy, however the SAE and AE leading to medication discontinuation were minimal and similar between the groups [87, 90] A programme of phase 3 clinical trials (REDEFINE) assessing the safety and efficacy of cagrisema in people with obesity (NCT05567796, NCT05394519, NCT05813925) is currently ongoing
Notably, 19% of patients on GLP-1 agonists develop delayed gastric emptying, with semaglutide posing a 3.3-fold higher gastroparesis risk than bupropion-naltrexone and 6.1-fold higher than sleeve gastrectomy [9]
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