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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

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Inducing ferroptosis or treating with IFN- in Institute of Cancer Research (ICR) mice exacerbates the symptoms of SS, while inhibition of ferroptosis or the IFN- signaling pathway in non-obese diabetic (NOD) mice models alleviates both ferroptosis in the salivary gland and SS symptoms