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So the safety issue I'm really, really concerned about

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They act on separate biological pathways and can be used together

In addition to the previously discussed nutrient-sensing and autophagy pathways, the molecular landscape of inflammaging further encompasses several key regulatory signaling pathways: the cGAS-STING, Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathways, Wnt/-catenin signaling, and Notch signaling