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Multiple strategies have been proposed to circumvent the neuropsychiatric adverse effects including biased signaling, allosteric modulators, neutral antagonists, and peripherally restricted ligands since several metabolic processes appear to benefit from peripheral blockade of CB1 (113115)

Some studies suggest that some traditional medicine-derived interventions may ameliorate fatigue-related central abnormalities by modulating HPA axis activity, oxidative stress, mitochondrial function, BDNF-related signaling, and monoaminergic neurotransmission (Surapaneni et al., 2012

The risks involved in use during pregnancy clearly outweigh potential benefits

GSTs from Gram positive bacteria are grouped into four different classes viz