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When combining the two, expect nausea to be most pronounced during dose escalation periods, particularly when both compounds are being increased in close succession

However, nausea depends primarily on dose escalation speed and individual GLP-1 receptor sensitivity rather than injection timing itself

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On August 21, 2024, Gilead registered a Phase I clinical trial for its small-molecule GLP-1 receptor agonist GS-4571 for diabetes and obesity treatment on ClinicalTrials.gov