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The muscle piece is important because muscle is a metabolic currency as we age

In terms of efficacy, GH and IGF-1 both stimulated linear growth but some variables including the greater growth deficit in infants with Laron syndrome than those with isolated growth hormone deficiency, insufficient IGF-1 dose, or the IGF-1 dependency on the GH-linked stem cell population of prechondrocytes made GH more efficient in terms of linear growth stimulation (170, 171)

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Regulation of skin barrier function via competition between Ahr axis versus Il-13/Il-4JakStat6/Stat3 axis: Pathogenic and therapeutic implications in atopic dermatitis