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2 and Supplementary Table 3) fulfilled all these criteria and included 1) HIF1A transcription factor network (pink), 2) hypoxic and oxygen hemostasis regulation of HIF1A (black), 3) Vascular Endothelial Growth Factor (VEGF) hypoxia and angiogenesis (blue), 4) HIF2A transcription factor network (green), 5) signaling by Transforming Growth Factor- (TGFB) receptor complex (brown), 6) signaling by Platelet Derived Growth Factor (PDGF, yellow), and 7) hypoxia response by HIF activation pathways (orange)

supplementation is a clinical necessity, not an optional measure

Anti-Inflammation: Reducing oxidative stress and suppressing pro-inflammatory molecules like TNF-alpha and IL-6

Their actions include reversing the Warburg effect, restoring mitochondrial oxidative metabolism, regulating lipid and amino acid homeostasis, and enhancing the arginine-NO pathway