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Acylation of the incretin peptide exendin-4 directly impacts glucagon-like peptide-1 receptor signaling and trafficking

4 Proffer SL et al

Thyroid considerations: Preclinical studies in rodents consistent with findings for other GLP-1 receptor agonists as a class have raised theoretical concerns regarding thyroid C-cell tumours

Planning for long-term or indefinite medication use represents a realistic approach rather than expecting temporary treatment to produce permanent results