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Clin Transl Sci 14(4):14641475

PMID: 2909810

At the same time, it reduces ubiquinone to dihydroubiquinone via electron transfer across the mitochondrial inner membrane ( Figure 1 ) ( An experimental analysis of a group of cancer cell lines with low and high GPX4 expression demonstrated that inhibiting DHODH could induce ferroptosis in tumor cells with low GPX4 expression while enhancing ferroptosis resistance in cancer cells with high GPX4 expression