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For instance, a meta-analysis demonstrated that SGLT2i/GLP-1 RA combination therapy lowered the incidence of HF and major adverse cardiac and cerebrovascular events more effectively than either agent alone [96]

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The triple-receptor approach extends the metabolic research effects of single-receptor (semaglutide) and dual-receptor (tirzepatide) predecessors by adding glucagon receptor activity which contributes to additional metabolic and energy expenditure pathways