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For men who do not respond to oral medications, second-line treatments include vacuum erection devices, intracavernosal injections (alprostadil), intraurethral therapy, or penile prosthesis surgery

(2023) Foslevodopa-Foscarbidopa (Vyalev): CADTH Reimbursement Recommendation: Indication: For the treatment of motor fluctuations in patients with advanced levodopa-responsive Parkinsons disease who do not have satisfactory control of severe, debilitating motor fluctuations and hyper-/dyskinesia despite optimized treatment with available combinations of Parkinsons medicinal products

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