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Heres where the hormonal interaction becomes practically important: if weight loss on GLP-1 therapy improves ovulatory function, particularly in women with PCOS or obesity-related anovulation, fertility may increase during treatment even if cycles were previously irregular or absent

The competitive landscape has seen significant activity and controversy

Postprandial renal haemodynamic effect of lixisenatide vs once-daily insulin-glulisine in patients with type 2 diabetes on insulin-glargine: an 8-week, randomised, open-label trial

For payers and plan sponsors this leads to three challenges: utilization is growing, treatment duration is extending, and visibility into outcomes remains limited