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Most commonly topical, sometimes injectable in certain settings, and occasionally in other delivery methods depending on the product landscape

Proc Natl Acad Sci U S A 95:29562960 Wachter A, Wolf S, Steininger H, Bogs J, Rausch T (2005a) Differential targeting of GSH1 and GSH2 is achieved by multiple transcription initiation: implications for the compartmentation of glutathione biosynthesis in the Brassicaceae

In cancer cells, increased ROS will oxidize the specific isoform of pyruvate kinase (PKM2), diverting glucose flux towards the PPP and generation of NADPH for GSH recycling

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