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15 Human serum albumin (HSA) and IgG have plasma half-lives of around 21 days, owing to HSA and the Fc domain of IgG interacting with the neonatal Fc receptor expressed in blood vessel endothelial cells, which rescues the proteins in the endosomes after pinocytosis, preventing them from entering the lysosomal pathway for destruction

Xie has received research support from the Parkinsons Foundation, the Michael J Fox Foundation for Parkinsons Research, AbbVie, Bristol-Myers Squibb, Biogen, and Bucksbaum Institute of Clinical Excellence (University of Chicago)

The medications are typically administered via subcutaneous injection (except for oral semaglutide/Rybelsus), either daily or weekly depending on the formulation

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