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Discussion The three trials summarized in TABLE 2 provide consistent evidence that GLP-1 RAs may be an advantageous alternative to prandial insulin as add-on therapy to basal insulin

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Considering the knowledge in the literature, we can conclude that: 1) the interaction between GLP-1R and Cav-1 is necessary not only for receptor trafficking to the cell membrane, but also for activation of the intracellular signaling pathway

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