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Most common side effects were gastrointestinal, with 24.5% of participants in the phase 2 obesity trial discontinuing efinopegdutide 10 mg due to AE however when the same dose was used with gradual escalation at the MASLD trial (starting dose 2.4 mg for 4 weeks, then 5 mg for 4 weeks and then 10 mg), only 5.6% of participants discontinued the medication due to AE
That work was furthered by another very recent paper specifically dedicated to GLP-1 receptor variants, with functional analysis of 60 loss-of-function GLP1R variants
Following his finding in Mutt's laboratory, Brown spent a sabbatical year at the University of Gttingen in the department of Werner Creutzfeldt, an expert in gastrointestinal endocrinology and strong proponent of the existence of the incretin concept
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