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SKU: 83173313679

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Description

L-Carnitine is an amino acid derivative that facilitates the movement of long-chain fatty acids into mitochondria

Using a targeted CRISPR knockout library consisting of 64 KGDDs, we discovered that trimethyllysine hydroxylase epsilon (TMLHE), the first and rate-limiting enzyme in de novo carnitine synthesis, is necessary for the survival of HR-proficient cells in the presence of DNA-damaging agents