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Research on MOTS-c in ovariectomized mice (a model for postmenopausal metabolic dysfunction) showed reduced fat accumulation in white adipose tissue, increased brown fat activation, and improved insulin sensitivity after just 5 weeks of treatment

Semaglutide (Ozempic for diabetes, Wegovy for weight loss) is a single GLP-1 receptor agonist

Some high-risk patients may benefit from non-GLP-1 weight loss medications or combination approaches that include behavioral coaching alongside lower doses of compounded therapy

During a September 2023 appearance on Talk TV's "Piers Morgan Uncensored," Osbourne described her experience taking Ozempic and cautioned others against using the drug