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In chronic unpredictable mild stress (CUMS) rat models, L-theanine could effectively improve the depressive-like behaviors of rats, which was regulated by monoamine neurotransmitters in the limbic-cortical-striatal-pallidal-thalamic-circuit related brain regions (57)
91(2): 1358 Chiechio S, Caricasole A, Barletta E, et al
However, there are two main concerns: Esophageal Cancer Drinking yerba mate at very high temperatures (boiling water) may increase the risk of esophageal cancer, similar to other hot beverages like coffee or tea
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