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Abbreviations ALS acid labile subunit BMP bone morphogenic protein COJ chondro-osseous junction FDA Food and Drug Administration FGF fibroblast growth factor GH growth hormone GHR/ growth hormone receptor knockout GnRH gonadotropin releasing hormone GP growth plate HZ hypertrophic zone of growth plate cartilage IGF-1 insulin-like growth factor 1 IGF-1R insulin-like growth factor 1 receptor IGF2 insulin-like growth factor 2 IGFBP insulin-like growth factor binding protein Ihh Indian hedgehog LID liver IGF-1-deficient LLD limb length discrepancy MAPK mitogen-activated protein kinase MMP-9 matrix metalloproteinase 9 MPM multiphoton microscopy PTHrP parathyroid hormone-related protein PZ proliferative zone of growth plate cartilage RZ reserve zone of growth plate cartilage T3 triiodothyronine TKI tyrosine kinase inhibitors TR1 thyroid hormone receptor alpha 1 TR thyroid hormone receptor beta VEGF vascular endothelial growth factor WISP3 Wnt induced secreted protein 3 Wnt wingless/integrated Zn zinc Footnotes Publisher's Disclaimer: This Author Accepted Manuscript is a PDF file of a an unedited peer-reviewed manuscript that has been accepted for publication but has not been copyedited or corrected

Management of endocrine disease: are all GLP-1 agonists equal in the treatment of type 2 diabetes

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Given that both peptide 15 and peptide 20 are modified forms of GCG (differed by 7 residues), ligand recognition patterns are highly conserved across the three peptides except for a few positions