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Yang J, Liu M, Hong D, Zeng M, Zhang X
Despite enormous efforts made by the global psychiatric research community, the molecular mechanism of MDD is not yet very clear
It is this pathway that is responsible for the bodys entire sulfur-based detoxification system
Further, a key glutathione-synthesizing enzyme, glutathione cysteine ligase modifier (GCLM), is decreased under oxidative stress.95 GCL dysregulation and deficit glutathione inhibit the detoxification of oxidative stress that results from dopamine metabolism and consequently lead to neural injury, especially in dopamine neuron-rich regions.9697 Glutathione is reduced in the prefrontal cortex and striatum,949899100 which are closely associated with the psychopathology of schizophrenia
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