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Muscle Weakness and Fatigue : Since muscles rely on fatty acids for energy, particularly during prolonged exercise or fasting, individuals with acylcarnitine deficiencies may experience muscle weakness, fatigue, and even rhabdomyolysis (muscle breakdown)

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doi: 10.3389/fcell.2020.00055 Received 26 October 2019 Accepted 22 January 2020 Published 07 February 2020 Volume 8 - 2020 Edited by Albena Todorova Dinkova-Kostova, University of Dundee, United Kingdom Reviewed by Wei-Hsiung Yang, Mercer University, United States

For instance, K-Ras mutations can induce glutamine dependency, with different mutations determining the extent of glutamine dependence (Brunelli et al, 2014)