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Description

The medication is typically initiated at 0.25 mg once weekly for four weeks (a non-therapeutic dose intended to improve gastrointestinal tolerability), then increased to 0.5 mg weekly

It is a spectrum of biochemical vulnerability

Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1

To assess the impact of post-randomization changes in metformin use, two sensitivity analyses were conducted for the CV outcomes: (1) censoring for initiation and discontinuation of metformin during the study using the Cox proportional hazards model described above