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(Mayo Clinic) Diet: creates the calorie deficit Exercise: increases energy expenditure, improves body composition, supports long-term maintenance Mayo Clinic specifically notes that combining regular activity with healthy eating is best for reaching and maintaining a healthy weight

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A body composition substudy of the Phase 2 diabetes trial, published in The Lancet Diabetes & Endocrinology in 2025, used DXA scans to measure changes in fat and lean mass in 189 participants