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Intrinsic primary afferent neurons may act as a neural starting point of gut-to-brain signaling (Perez-Burgos et al., GRAPHICAL ABSTRACT Bacteria can infiltrate the gut (Prez-Berezo et al., 2015), which subsequently modulated primary afferent nerve fibers via synaptic connections (Bellono et al., Electrically-excitable enteroendocrine L-cells are embedded in the epithelium and secrete glucagon-like peptide-1 (GLP-1) from their basolateral face following stimulation (Chimerel et al., 2017) and rats (Kuhre et al., in vitro colonic L-cells express bile receptors and receptors for short-chain fatty acids (Tolhurst et al., 2012)

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The key ingredient is the potent antioxidant Glutathione